TRPV2-selective blocker 1

Names

[ CAS No. ]:
2242724-49-6

[ Name ]:
TRPV2-selective blocker 1

Biological Activity

[Description]:

TRPV2-selective blocker 1 (compound IV2-1) is a selective TRPV2 channel blocker with an IC50 of 6.3 μM. TRPV2-selective blocker 1 does not affect TRPV1, TRPV3 or TRPV4 channels. TRPV2-selective blocker 1 also inhibits TRPV2-mediated Ca2+ influx in macrophages, and inhibits macrophage phagocytosis[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel
Research Areas >> Neurological Disease

[Target]

TRPV2:6.3 μM (IC50)


[References]

[1]. Rick Raudszus, et al. Pharmacological inhibition of TRPV2 attenuates phagocytosis and lipopolysaccharide-induced migration of primary macrophages. Br J Pharmacol. 2023 Nov;180(21):2736-2749.  

Chemical & Physical Properties

[ Molecular Formula ]:
C15H18OS2

[ Molecular Weight ]:
278.43

Related Compounds

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