2242724-49-6

2242724-49-6 structure

Name: TRPV2-selective blocker 1
Chemical Name: TRPV2-selective blocker 1
CAS Number: 2242724-49-6
Molecular Formula: C₁₅H₁₈OS₂
Molecular Weight: 278.43
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2024-01-08 19:49:49
Modify Date: 2024-01-08 19:49:49
TRPV2-selective blocker 1 (compound IV2-1) is a selective TRPV2 channel blocker with an IC50 of 6.3 μM. TRPV2-selective blocker 1 does not affect TRPV1, TRPV3 or TRPV4 channels. TRPV2-selective blocker 1 also inhibits TRPV2-mediated Ca2+ influx in macrophages, and inhibits macrophage phagocytosis[1].

Name	TRPV2-selective blocker 1

Description	TRPV2-selective blocker 1 (compound IV2-1) is a selective TRPV2 channel blocker with an IC50 of 6.3 μM. TRPV2-selective blocker 1 does not affect TRPV1, TRPV3 or TRPV4 channels. TRPV2-selective blocker 1 also inhibits TRPV2-mediated Ca2+ influx in macrophages, and inhibits macrophage phagocytosis[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease
Target	TRPV2:6.3 μM (IC50)
References	[1]. Rick Raudszus, et al. Pharmacological inhibition of TRPV2 attenuates phagocytosis and lipopolysaccharide-induced migration of primary macrophages. Br J Pharmacol. 2023 Nov;180(21):2736-2749.

Molecular Formula	C₁₅H₁₈OS₂
Molecular Weight	278.43