Omodenbamab

Names

[ Name ]:
Omodenbamab

Biological Activity

[Description]:

Omodenbamab is an anti-SpA (Staphylococcal protein A) humanized monoclonal antibody with a KD value of 0.0467 nM. Omodenbamab circumvents a key S. aureus evasion mechanism by targeting the cell wall moiety Protein A (SpA). Omodenbamab can be used in research of S. aureus bloodstream infection[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Omodenbamab (514-G3)与 S. aureus 结合并使 Fc 区暴露以供 FcγR1A 受体结合[1]。Omodenbamab (10 μg/mL; 30 min, 1.5 hr, and 2.5 hr) 支持人类血细胞对 S. aureus 的调理吞噬作用[1]。

[In Vivo]

Omodenbamab (514-G3; 2.5 mg/mice and 10 mg/mice; i.v.) 在菌血症模型中保护小鼠免受 MRSA 的致死攻击[1]。 Animal Model: Balb/C mice with MRSA in a bacteremia model[1] Dosage: 2.5 mg/mice and 10 mg/mice Administration: Intravenous injection Result: Increased mouse Balb/C mice with MRSA in a bacteremia model survival.

[References]

[1]. Varshney AK, et, al. A natural human monoclonal antibody targeting Staphylococcus Protein A protects against Staphylococcus aureus bacteremia. PLoS One. 2018 Jan 24;13(1):e0190537.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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