αvβ1 integrin-IN-2

Names

[ CAS No. ]:
2234874-68-9

[ Name ]:
αvβ1 integrin-IN-2

Biological Activity

[Description]:

αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of integrins ανβ1 and α5β1 with IC50s of 0.9 nM，and 33 nM，respectively. αvβ1 integrin-IN-2 also inhibits other integrins with ，，IC50s of 380 nM (ανβ3)，280 nM (ανβ5)，230 nM (ανβ6)，87 nM (ανβ8)，respectively，in SPRA assay[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Cytoskeleton >> Integrin

[References]

[1]. Ruminski PG, et al. Preparation of ((tetrahydronaphthyridinylethoxy)pyrazolyl) butanoic acid as integrin antagonists for the treatment and prevention of diseases. World Intellectual Property Organization, WO2018132268 A1. 2018-07-19.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H38N4O4

[ Molecular Weight ]:
506.64

Related Compounds