SHR1653

Names

[ CAS No. ]:
2231770-73-1

[ Name ]:
SHR1653

Biological Activity

[Description]:

SHR1653 is a highly potent, selective and brain penetrated oxytocin receptor (OTR) antagonist, with an IC50 of 15 nM for hOTR[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Oxytocin Receptor
Research Areas >> Neurological Disease

[Target]

IC50: 15 nM (hOTR)[1].


[References]

[1]. Li X, et al. Discovery of SHR1653, a Highly Potent and Selective OTR Antagonist with Improved Blood-Brain Barrier Penetration. ACS Med Chem Lett. 2019 May 29;10(6):996-1001.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H21ClFN5O2

[ Molecular Weight ]:
429.88