Tuberculosis inhibitor 1

Names

[ CAS No. ]:
2230810-28-1

[ Name ]:
Tuberculosis inhibitor 1

Biological Activity

[Description]:

Tuberculosis inhibitor 1 is a potent and non-cytotoxic trypanosoma brucei growth inhibitor with an EC50 of 5 nM[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

EC50: 5 nM (Trypanosoma brucei)[1]


[In Vitro]

Tuberculosis inhibitor 1 is selective over other parasites, such as Trypanosoma cruzi and Plasmodium falciparum (T. cruzi EC50 8120 nM, P. falciparum EC50 3624 nM)[1].

[References]

[1]. Ferrigno F, et al. Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitorsof Trypanosoma brucei growth in vitro. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3689-3692.

Chemical & Physical Properties

[ Molecular Formula ]:
C34H37N5O3

[ Molecular Weight ]:
563.69

Related Compounds