TLR9-IN-1

Names

[ Name ]:
TLR9-IN-1

Biological Activity

[Description]:

TLR9-IN-1 is a potent and selective TLR9 inhibitor with an IC50 value of 7 nM for human TLR9. TLR9-IN-1 can be used for researching diseases associated with undesirable immune response[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)

Research Areas >> Inflammation/Immunology

[Target]

human TLR9:7 nM (IC50)

[In Vitro]

TLR9-IN-1 (compound no.29) (0-10 μM; 24 h) exhibits moderately inhibitory activity against IL-1b with an IC50 of 1.61 μM in human monocytes (co-incubated with TLR8 agonist ORN8L, RNA oligonucleotide)[1].

[References]

[1]. Albert Frederick Candia, et al. Toll-like receptor antagonist compounds and methods of use. WO2018089695

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₃₁N₇O

[ Molecular Weight ]:
421.54

Related Compounds

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