GluN2B receptor modulator-1

Names

[ CAS No. ]:
2222010-71-9

[ Name ]:
GluN2B receptor modulator-1

Biological Activity

[Description]:

GluN2B receptor modulator-1 is a selective GluN2B negative allosteric modulator with an IC50 value of 31 nM.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Chrovian CC, et al. Design, Synthesis, and Preclinical Evaluation of 3-Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders. J Med Chem. 2020 Sep 10;63(17):9181-9196.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₅F₃N₄O₂S

[ Molecular Weight ]:
396.39

Related Compounds

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