SC 221409

Names

[ CAS No. ]:
222035-13-4

[ Name ]:
SC 221409

[Synonym ]:
4-[(2Z)-2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazinyl]benzenesulfonamide
4-[(2Z)-2-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]benzenesulfonamide
Benzenesulfonamide, 4-[(2Z)-2-(5-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazinyl]-

Biological Activity

[Description]:

CDK2-IN-3 (compound 3) is a potent and selective CDK2 inhibitor with an 50 of 60 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK2:60 nM (IC50)

[References]

[1]. S T Davis, et al. Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors. Science. 2001 Jan 5;291(5501):134-7.

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Molecular Formula ]:
C₁₄H₁₁BrN₄O₃S

[ Molecular Weight ]:
395.231

[ Exact Mass ]:
393.973511

[ PSA ]:
122.03000

[ LogP ]:
2.53

[ Index of Refraction ]:
1.769

Related Compounds

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