Atuzaginstat

Names

[ CAS No. ]:
2211981-76-7

[ Name ]:
Atuzaginstat

Biological Activity

[Description]:

Atuzaginstat (COR388) is an effective small-molecule bacterial protease lysine gingipain inhibitor and can be used for the research of Alzheimer's disease[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Lysine gingipain[1]

[References]

[1]. Arastu-Kapur, S., et al. 676 PD-L1 is induced by the periodontal pathogen porphyromonas gingivalis and can be blocked by small molecule gingipain inhibitors, including atuzaginstat. Journal for Immuno Therapy of Cancer. 2020; 8(Suppl 3): A715-A715.

[2]. Cortexyme Presents an Update and Baseline Data from the Phase 2/3 GAIN Trial of Atuzaginstat at CTAD 2020, the Clinical Trials on Alzheimer’s Disease Conference.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₅F₃N₂O₃

[ Molecular Weight ]:
386.41

Related Compounds

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