Pexelizumab

Names

[ CAS No. ]:
219685-93-5

[ Name ]:
Pexelizumab

Biological Activity

[Description]:

Pexelizumab (h5G1. 1-SC) is a humanized scFv monoclonal antibody directed against the C5 complement component. Pexelizumab inhibits apoptosis and leukocyte infiltration. Pexelizumab can be used for the research of cerebral IR injury and myocardial infarction[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Immunology/Inflammation >> Complement System

Research Areas >> Neurological Disease

[In Vitro]

Pexelizumab (h5G1. 1-SC) 抑制 5G1.1 单抗的结合，IC50 为 1.5 nM[2]。

[References]

[1]. APEX AMI Investigators, et al. Pexelizumab for acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronary intervention: a randomized controlled trial. JAMA. 2007 Jan 3;297(1):43-51.

[2]. Thomas TC, et al. Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv. Mol Immunol. 1996 Dec;33(17-18):1389-401.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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