219685-93-5

219685-93-5 structure

Name: Pexelizumab
Chemical Name: h5G1.1-scFv
CAS Number: 219685-93-5
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-03-11 12:57:55
Modify Date: 2024-04-09 16:33:12
Pexelizumab (h5G1. 1-SC) is a humanized scFv monoclonal antibody directed against the C5 complement component. Pexelizumab inhibits apoptosis and leukocyte infiltration. Pexelizumab can be used for the research of cerebral IR injury and myocardial infarction[1][2].

Name	h5G1.1-scFv

Description	Pexelizumab (h5G1. 1-SC) is a humanized scFv monoclonal antibody directed against the C5 complement component. Pexelizumab inhibits apoptosis and leukocyte infiltration. Pexelizumab can be used for the research of cerebral IR injury and myocardial infarction[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> Complement System Research Areas >> Neurological Disease
In Vitro	Pexelizumab (h5G1. 1-SC) 抑制 5G1.1 单抗的结合，IC50 为 1.5 nM[2]。
References	[1]. APEX AMI Investigators, et al. Pexelizumab for acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronary intervention: a randomized controlled trial. JAMA. 2007 Jan 3;297(1):43-51. [2]. Thomas TC, et al. Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv. Mol Immunol. 1996 Dec;33(17-18):1389-401.

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