TH34

Names

[ CAS No. ]:
2196203-96-8

[ Name ]:
TH34

Biological Activity

[Description]:

TH34, an HDAC6/8/10 inhibitor with IC50s of 4.6 μM, 1.9 μM, and 7.7 μM respectively, shows high selectivity over HDAC1/2/3[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC6:4.6 μM (IC50)

HDAC8:1.9 μM (IC50)

HDAC10:7.7 μM (IC50)

[In Vitro]

TH34 induces caspase-dependent programmed cell death and cell cycle arrest in neuroblastoma cells[1].

[References]

[1]. Kolbinger FR, et al. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₆N₂O₂

[ Molecular Weight ]:
256.30

[ Storage condition ]:
2-8℃

Related Compounds

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