2196203-96-8

2196203-96-8 structure

Name: TH34
Chemical Name: TH34
CAS Number: 2196203-96-8
Molecular Formula: C₁₅H₁₆N₂O₂
Molecular Weight: 256.30
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2019-06-30 09:26:15
Modify Date: 2024-01-02 12:29:24
TH34, an HDAC6/8/10 inhibitor with IC50s of 4.6 μM, 1.9 μM, and 7.7 μM respectively, shows high selectivity over HDAC1/2/3[1].

Name	TH34

Description	TH34, an HDAC6/8/10 inhibitor with IC50s of 4.6 μM, 1.9 μM, and 7.7 μM respectively, shows high selectivity over HDAC1/2/3[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC6:4.6 μM (IC50) HDAC8:1.9 μM (IC50) HDAC10:7.7 μM (IC50)
In Vitro	TH34 induces caspase-dependent programmed cell death and cell cycle arrest in neuroblastoma cells[1].
References	[1]. Kolbinger FR, et al. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664.