VU6005806

Names

[ Name ]:
VU6005806

Biological Activity

[Description]:

VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[Target]

IC50: 94 nM (Human M4), 28 nM (Rat M4), 87 nM (Dog M4), 68 nM (Cyno M4)[1]

[References]

[1]. Engers DW, et al. VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1714-1718.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₆F₃N₇O₂S

[ Molecular Weight ]:
439.41

Related Compounds

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