Curcolonol

Names

[ Name ]:
Curcolonol

[Synonym ]:
(4aR,5R,8R,8aR)-5,8-Dihydroxy-3,5,8a-trimethyl-5,6,7,8,8a,9-hexahydronaphtho[2,3-b]furan-4(4aH)-one
Naphtho[2,3-b]furan-4(4aH)-one, 5,6,7,8,8a,9-hexahydro-5,8-dihydroxy-3,5,8a-trimethyl-, (4aR,5R,8R,8aR)-

Biological Activity

[Description]:

Curcolonol is a furan type sesquiterpene. Curcolonol can be isolated from several medical herbs. Curcolonol has inhibitory activity for LIM kinase 1. Curcolonol can be used for the research of breast cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> LIM Kinase (LIMK)

[References]

[1]. Hong Lu, et al. Curcolonol suppresses the motility of breast cancer cells by inhibiting LIM kinase 1 to downregulate cofilin 1 phosphorylation. Int J Oncol. 2018 Dec;53(6):2695-2704.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
424.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₀O₄

[ Molecular Weight ]:
264.317

[ Flash Point ]:
210.7±28.7 °C

[ Exact Mass ]:
264.136169

[ LogP ]:
2.35

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.570

Related Compounds

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