LY2794193

Names

[ Name ]:
LY2794193

Biological Activity

[Description]:

LY2794193 is a highly potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM，EC50=0.47 nM; hmGlu2 Ki=412 nM，EC50=47.5 nM)[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[Target]

mGluR3:0.47 nM (EC50)

mGluR3:0.927 nM (Ki)

mGluR2:47.5 (EC50)

mGluR2:412 (Ki)

[References]

[1]. Monn JA, et al. Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist. J Med Chem. 2018 Mar 22;61(6):2303-2328.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₈N₂O₆

[ Molecular Weight ]:
334.32

[ Storage condition ]:
2-8°C

Related Compounds

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