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Esomeprazole magnesium

Names

[ CAS No. ]:
217087-09-7

[ Name ]:
Esomeprazole magnesium

[Synonym ]:
Esomeprazole magnesium trihydrate
1H-Benzimidazole, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-, magnesium salt, hydrate (2:1:3)
Esomeprazole magnesium
EINECS 111-111-1
Magnesium 5-methoxy-2-{[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl}benzimidazol-1-ide hydrate (1:2:3)
Omeprazole magnesium trihydrate
MFCD07698573
Magnesium 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}benzimidazol-1-ide hydrate (1:2:3)
(S)-Omeprazole magnesium trihydrate
Esomeprazole (Magnesium trihydrate)

Biological Activity

[Description]:

Esomeprazole Magnesium trihydrate is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.IC50 value:Target: proton pumpEsomeprazole sodium (Nexium) is the S-isomer of omeprazole and acts as a proton pump inhibitor and gastric antisecretory agent indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis. Esomeprazole 0.4 and 0.8 mg/mL as the sodium salt in the infusion solutions tested is chemically and physically stable for at least 2 days at room temperature and 5 days under refrigeration.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump
Research Areas >> Others

[References]

[1]. Sandstr?m M, Davidson G, Tolia V et al. Phase I, multicenter, randomized, open-label study evaluating the pharmacokinetics and safety profile of repeated once-daily doses of intravenous esomeprazole in children 0 to 17 years of age. Clin Ther. 2012 Aug;34(8):1828-38.

[2]. Wang-Smith L, Fort J, Zhang Y, Sostek M. Pharmacokinetics and relative bioavailability of a fixed-dose combination of enteric-coated naproxen and non-enteric-coated esomeprazole magnesium. J Clin Pharmacol. 2012 May;52(5):670-80.

[3]. Johnson TJ, Hedge DD. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9.

[4]. Esomeprazole


[Related Small Molecules]

Bafilomycin A1 | omeprazole | Vonoprazan Fumarate (TAK-438) | Zinc Pyrithione | Lansoprazole | Ilaprazole | AZD0865 | Soraprazan | bamaquimast | Esomeprazole | Esomeprazole sodium | Chebulinic acid | Picoprazole | SKF96067 | Pumaprazole

Chemical & Physical Properties

[ Boiling Point ]:
600ºC at 760 mmHg

[ Melting Point ]:
184-189ºC (dec.)

[ Molecular Formula ]:
C34H42MgN6O9S2

[ Molecular Weight ]:
767.167

[ Flash Point ]:
316.7ºC

[ Exact Mass ]:
766.230530

[ PSA ]:
198.59000

[ LogP ]:
6.90950

[ Vapour Pressure ]:
2.35E-14mmHg at 25°C

[ Storage condition ]:
-20°C Freezer

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

Related Compounds