Esomeprazole

Names

[ CAS No. ]:
161973-10-0

[ Name ]:
Esomeprazole

[Synonym ]:
(-)-Omeprazole magnesium
Nexium
H-199/18
omeprazole magnesium
EsMeprazole Magne-siuM Trihydrate
sulfonium, hydroxy(6-methoxy-1H-benzimidazol-2-yl)[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-, inner salt, magnesium salt (2:1)
H 199/18
(T-4-(S),(S))-Bis(5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazolato)magnesium
(S)-Omeprazole magnesium
(T-4)-Bis(5-methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl-kO)-1H-benzimidazolato-kN1)magnesium
Magnesium bis(5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl}benzimidazol-1-ide)
Esomeprazole magnesium
1H-Benzimidazole, 5-methoxy-2-[(S)-[(1S)-(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-, magnesium salt (2:1)
Magnesium bis{(6-methoxybenzimidazol-1-id-2-yl)[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfoniumolate}
Magnesium bis(5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}benzimidazol-1-ide)
Esomeprazole

Biological Activity

[Description]:

Esomeprazole magnesium is an inhibitor of H+, K+-ATPase, effectively used in the research of upper intestinal disorder.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump

Research Areas >> Others

[Target]

H+, K+-ATPase[1]

[In Vitro]

Esomeprazole magnesium is an inhibitor of H+, K+-ATPase[1].

[In Vivo]

Esomeprazole magnesium (0.5, 5, 50 mg/kg/day, p.o.) produces increased gastric total antioxidant capacity, decreases gastric lipid peroxide levels, significantly increases superoxide dismutase levels, but shows no obvious effect on colonic lipid peroxide levels in mice[1].

[Animal admin]

Mice[1] In this 10-day supplementation experiment, mice (n = 10/group) receive the following: 1) as a control group, only the vehicle for dissolution of Esomeprazole (PEG-400) given orally once daily by gastric gavage; 2) Esomeprazole 0.5 mg/kg in an equivalent volume of PEG-400 given orally once daily by gastric lavage; 3) Esomeprazole 5 mg/kg in an equivalent volume of PEG-400 given orally once daily by gastric lavage; and 4) Esomeprazole 50 mg/kg in an equivalent volume of PEG-400 given orally once daily by gastric lavage[1].

[References]

[1]. Koch TR, et al. Effect of the H, K-ATPase inhibitor, esomeprazole magnesium, on gut total antioxidant capacity in mice. J Nutr Biochem. 2004 Sep;15(9):522-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
600ºC at 760 mmHg

[ Molecular Formula ]:
C₃₄H₃₆MgN₆O₆S₂

[ Molecular Weight ]:
713.121

[ Flash Point ]:
316.7ºC

[ Exact Mass ]:
712.198792

[ PSA ]:
186.82000

[ LogP ]:
6.78900

[ Vapour Pressure ]:
2.35E-14mmHg at 25°C

[ Storage condition ]:
-20℃

Related Compounds

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