TGFBR1-IN-1

Names

[ CAS No. ]:
2170830-26-7

[ Name ]:
TGFBR1-IN-1

Biological Activity

[Description]:

TGFBR1-IN-1 is an ALK5 inhibitor extracted from patent WO2018004290A1, Compound 33, has an IC50 of 10-100 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[Target]

ALK5:10-100 nM (IC50)

[In Vitro]

Transforming Growth Factor-β (TGF-β) signaling regulates various cellular responses such as cell proliferation, differentiation, cell migration and cell death. TGF-β has at least three isoforms TGF-β1, TGF-β2 and TGF-β3. TGF-β1 is two well-conserved single membrane serine/threonine kinase type I (ALK5). ALK5 inhibitos can be used for treating fibrotic disease, tumor, inflammatory disease, and autoimmune disease[1].

[References]

[1]. Novel pyrazole derivative as alk5 inhibitor and uses thereof. WO2018004290A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₇N₅O₂S

[ Molecular Weight ]:
427.48

Related Compounds

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