2170830-26-7
2170830-26-7 structure
- Name: TGFBR1-IN-1
- Chemical Name: TGFBR1-IN-1
- CAS Number: 2170830-26-7
- Molecular Formula: C23H17N5O2S
- Molecular Weight: 427.48
- Catalog: Research Areas Cancer
- Create Date: 2020-04-09 14:21:12
- Modify Date: 2025-08-25 11:04:48
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TGFBR1-IN-1 is an ALK5 inhibitor extracted from patent WO2018004290A1, Compound 33, has an IC50 of 10-100 nM[1].
| Name | TGFBR1-IN-1 |
|---|
| Description | TGFBR1-IN-1 is an ALK5 inhibitor extracted from patent WO2018004290A1, Compound 33, has an IC50 of 10-100 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
ALK5:10-100 nM (IC50) |
| In Vitro | Transforming Growth Factor-β (TGF-β) signaling regulates various cellular responses such as cell proliferation, differentiation, cell migration and cell death. TGF-β has at least three isoforms TGF-β1, TGF-β2 and TGF-β3. TGF-β1 is two well-conserved single membrane serine/threonine kinase type I (ALK5). ALK5 inhibitos can be used for treating fibrotic disease, tumor, inflammatory disease, and autoimmune disease[1]. |
| References |
[1]. Novel pyrazole derivative as alk5 inhibitor and uses thereof. WO2018004290A1. |
| Molecular Formula | C23H17N5O2S |
|---|---|
| Molecular Weight | 427.48 |