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Ac-Ile-Glu-Pro-Asp-AMC

Names

[ CAS No. ]:
216757-33-4

[ Name ]:
Ac-Ile-Glu-Pro-Asp-AMC

[Synonym ]:
ac-ile-glu-pro-asp-7-amino-4-methylcoumarin
L-α-Asparagine, N-acetyl-L-isoleucyl-L-α-glutamyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
granzyme b substrate ix,fluorogenic
ac-ile-glu-pro-asp-amc
N-Acetyl-L-isoleucyl-L-α-glutamyl-L-prolyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-α-asparagine
n-acetyl-ile-glu-pro-asp-7-amido-4-methylcoumarin

Biological Activity

[Description]:

Ac-IEPD-AMC is a fluorogenic substrate for the determination of protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Scott JI, et, al. A Functional Chemiluminescent Probe for in Vivo Imaging of Natural Killer Cell Activity Against Tumours. Angew Chem Int Ed Engl. 2021 Mar 8;60(11):5699-5703.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1116.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C32H41N5O11

[ Molecular Weight ]:
671.69

[ Flash Point ]:
628.7±34.3 °C

[ Exact Mass ]:
671.280273

[ PSA ]:
241.52000

[ LogP ]:
1.98

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.593

Safety Information

[ WGK Germany ]:
3

Related Compounds