Ac-Ile-Glu-Thr-Asp-AMC

Names

[ Name ]:
Ac-Ile-Glu-Thr-Asp-AMC

[Synonym ]:
L-α-Asparagine, N-acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
N-Acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-α-asparagine

Biological Activity

[Description]:

Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. V Frost, et al. Exploitation of a non-apoptotic caspase to regulate the abundance of the cdkI p27(KIP1) in transformed lymphoid cells. Oncogene. 2001 May 17;20(22):2737-48.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1157.6±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₁H₄₁N₅O₁₂

[ Molecular Weight ]:
675.683

[ Flash Point ]:
653.9±34.3 °C

[ Exact Mass ]:
675.275146

[ PSA ]:
287.99000

[ LogP ]:
1.24

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.585

Related Compounds

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