Z-Ile-Glu-Thr-Asp-AFC

Names

[ CAS No. ]:
219138-02-0

[ Name ]:
Z-Ile-Glu-Thr-Asp-AFC

[Synonym ]:
MFCD01318832
(4S)-5-[[(2S,3R)-1-[[(2S)-3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[[(2S,3S)-3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoic acid
Cbz-IETD-AFC
Z-Ile-Glu-Thr-Asp-AFC
Z-IETD-AFC

Biological Activity

[Description]:

Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Boudard D, et al. Increased caspase-3 activity in refractory anemias: lack of evidence for Fas pathway implication. Leukemia. 2002;16(11):2343-2345.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₇H₄₂F₃N₅O₁₃

[ Molecular Weight ]:
821.75000

[ Exact Mass ]:
821.27300

[ PSA ]:
279.77000

[ LogP ]:
3.90270

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro.

J. Biol. Chem. 272 , 13432-13436, (1997)

The apoptotic cysteine protease, caspase-3, is expressed in cells as an inactive 32-kDa precursor from which 17 kDa (p17) and 12 kDa (p12) subunits of the mature caspase-3 are proteolytically generate...