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Pipazethate

Names

[ CAS No. ]:
2167-85-3

[ Name ]:
Pipazethate

[Synonym ]:
4-Aza-phenothiazin-10-carbonsaeure-piperidino-aethoxy-aethylester
Pipazetato [INN-Spanish]
Pipazetate
Pipazetatum [INN-Latin]
pipazethate
Theratuss
benzo[b]pyrido[2,3-e][1,4]thiazine-10-carboxylic acid 2-(2-piperidin-1-yl-ethoxy)-ethyl ester
Lenopect

Biological Activity

[Description]:

Pipazethate (SKF 70230A), a pyridobenzothiazine derivative, is a potent GABA antagonist. Pipazethate has antitussive activity. Pipazethate can be used in research in cough supressant[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Boiling Point ]:
553.3ºC at 760mmHg

[ Molecular Formula ]:
C21H25N3O3S

[ Molecular Weight ]:
399.50700

[ Flash Point ]:
288.4ºC

[ Exact Mass ]:
399.16200

[ PSA ]:
80.20000

[ LogP ]:
4.32630

[ Vapour Pressure ]:
2.76E-12mmHg at 25°C

[ Index of Refraction ]:
1.612

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU8485000
CHEMICAL NAME :
10H-Pyrido(3,2-b)(1,4)benzothiazine-10-carboxylic acid, 2-(2-(1-piperidinyl)ethoxy) ethyl ester
CAS REGISTRY NUMBER :
2167-85-3
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H25-N3-O3-S
MOLECULAR WEIGHT :
399.55

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
94647 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 188,189,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13140 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 188,189,1970

Synthetic Route

Precursor & DownStream


Related Compounds

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