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beta-Pompilidotoxin

Names

[ CAS No. ]:
216064-36-7

[ Name ]:
beta-Pompilidotoxin

[Synonym ]:
RIKIGLFDQLSRL-NH2
Beta-Pompilidotoxin
b-Pompilidotoxin

Biological Activity

[Description]:

β-Pompilidotoxin (β-PMTX), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Neurological Disease

[In Vitro]

β-Pompilidotoxin (β-PMTX) increases resurgent current in wild-type neurons and induced resurgent current in med neurons. β-Pompilidotoxin (10 μM) modestly but significantly increased the decay time constant (τdecay) of currents evoked by a step from -90 to 0 mV from 0.52 to 0.73 msec in wild-type Purkinje cells[1].

[References]

[1]. Tina M Grieco, et al. Production of resurgent current in NaV1.6-null Purkinje neurons by slowing sodium channel inactivation with beta-pompilidotoxin. J Neurosci. 2004 Jan 7;24(1):35-42.

Chemical & Physical Properties

[ Molecular Formula ]:
C71H124N22O17

[ Molecular Weight ]:
1557.88000

[ Exact Mass ]:
1556.95000

[ PSA ]:
668.75000

[ LogP ]:
4.98310

Safety Information

[ WGK Germany ]:
3

Related Compounds