KRAS G12C inhibitor 11

KRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147[1].

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Ras

KRas G12C[1]

Kirsten Rat Sarcoma 2 Viral Oncogene Homolog (KRas) is a small GTPase and a member of the Ras family of oncogenes. KRas serves a molecular switch cycling between inactive (GDP -bound) and active (GTP -bound) states to transduce upstream cellular signals received from multiple tyrosine kinases to downstream effectors to regulate a wide variety of processes, including cellular proliferation[1].

[1]. John P. Fischer, et al. Kras g12c inhibitors. WO2017201161A1.