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KRAS G12C inhibitor 25

Names

[ CAS No. ]:
2734060-73-0

[ Name ]:
KRAS G12C inhibitor 25

Biological Activity

[Description]:

KRAS G12C inhibitor 25 is a KRAS G12C inhibitor. KRAS G12C inhibitor 25 inhibits SOSl-assisted GDP/GTP exchanging activity of KRAS-G12C mutant (IC50=0.48 nM). From WO2021216770A1 compound 3[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRas G12C


[References]

[1]. Yimin Qian, et al. Substituted tetrahydroquinazoline compounds as kras inhibitors. WO2021216770A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H41N7O2

[ Molecular Weight ]:
555.71

Related Compounds