guatteguamerine

Names

[ Name ]:
guatteguamerine

[Synonym ]:
7-Isoquinolinol,1,2,3,4-tetrahydro-1-((4-(2-hydroxy-5-((1,2,3,4-tetrahydro-7-hydroxy-6-methoxy-2-methyl-1-isoquinolinyl)methyl)phenoxy)phenyl)methyl)-6-methoxy-2-methyl-,(R-(R*,R*))
Guatteguamerine
(1R)-1-[4-(2-hydroxy-5-{[(1R)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}phenoxy)benzyl]-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol
Dauriciline
(1R)-1-[[4-[2-hydroxy-5-[[(1R)-7-hydroxy-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]phenoxy]phenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
N,N'-Dimethyllindoldhamine
Guattegaumerine
7,7'-Demethyldauricine

Biological Activity

[Description]:

Guattegaumerine is a bisbenzylisoquinoline alkaloid with antimitotic, cytotoxic and neuroprotective activities[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

Guattegaumerine (1.25-6.25 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) significantly increases cell viability at 1.25 and 2.5μM; and guattegaumerine pretreatment significantly inhibits LDH efflux[1]. Guattegaumerine (2.5 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) markedly reduces the oxidative stress-induced apoptosis in rat cortical neurons when compares with the control group[1]. Guattegaumerine (1.25-2.5 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) decreases H2O2 and KCl induced Ca[2+]i increase in cortical neurons[1].

[References]

[1]. Qing Lü, et al. Guattegaumerine protects primary cultured cortical neurons against oxidative stress injury induced by hydrogen peroxide concomitant with serum deprivation. Cell Mol Neurobiol. 2009 May;29(3):355-64.

[2]. J Leclercq, et al. Antimitotic and cytotoxic activities of guattegaumerine, a bisbenzylisoquinoline alkaloid. Planta Med

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₆H₄₀N₂O₆

[ Molecular Weight ]:
596.71300

[ Exact Mass ]:
596.28900

[ PSA ]:
94.86000

[ LogP ]:
6.03210

[ Vapour Pressure ]:
1.54E-22mmHg at 25°C

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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