4-AMinophenylboronic acid pinacol ester

Names

[ Name ]:
4-AMinophenylboronic acid pinacol ester

[Synonym ]:
4-AMINOBENZENEBORONIC ACID PINACOL ESTE
4-AMINOPHENYLBORONIC ACID PINACOL CYCLIC ESTER
4-METHYLPHENYLBORONIC ACID PINACOLATE
4-AMINOPHENYLBORONIC ACID PINACOLATE
MFCD02258965
4-aminobenzeneboronic acid pinacol ester
2-(4-Aminophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
4-Aminophenylboronic Acid Pinacol Ester
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Biological Activity

[Description]:

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline 是一种杂环结构单元。它已用于合成基于 3-氨基吲唑的多靶点受体具有抗癌活性的酪氨酸激酶 (RTK) 抑制剂和 roscovitine 衍生物，它们是细胞周期蛋白依赖性激酶 (CDK) 和酪蛋白激酶 1 (CK1) 的双重抑制剂。

[References]

[1]. Dai, Y., Hartandi, K., Ji, Z., et al al. Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based ORALLY ACTIVE MULTITARGED Receptor Tyrosine Kinase Inchibitorj. Chem.50 (7) 1584-1597 (2007).

[2]. Paraiso, KHT, HAARBERG, He, Wood, E., ET Al.The HSP9 0 Inhibitor XL888 Overcomes Braf Inchibitor Resistance Mediated Through diverse mechanisms Clin. Cancer Res. 18(9) 2502-2514(2012).

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
340.0±25.0 °C at 760 mmHg

[ Melting Point ]:
165-169 °C(lit.)

[ Molecular Formula ]:
C₁₂H₁₈BNO₂

[ Molecular Weight ]:
219.09

[ Flash Point ]:
159.4±23.2 °C

[ Exact Mass ]:
219.143066

[ PSA ]:
44.48000

[ LogP ]:
2.14920

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.517

[ Storage condition ]:
Refrigerator (+4°C)

[ Water Solubility ]:
Insoluble

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ WGK Germany ]:
3

[ HS Code ]:
2931900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%