4-Bromoaniline

Names

[ CAS No. ]:
106-40-1

[ Name ]:
4-Bromoaniline

[Synonym ]:
para bromo aniline
para-bromoaniline
Benzenamine,4-bromo
4-bromo-aniline
4-bromobenzenamide
4-Bromoaniline
EINECS 203-393-9
4-Bromobenzenamine
ZR DE
MFCD00007822
P-BROMOANILINE
Aniline,p-bromo
Benzenamine, 4-bromo-
p-Bromophenylamine
1-amino-4-bromobenzene
4-bromo-phenylamine

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
225.9±13.0 °C at 760 mmHg

[ Melting Point ]:
56-62 °C(lit.)

[ Molecular Formula ]:
C₆H₆BrN

[ Molecular Weight ]:
172.023

[ Flash Point ]:
90.4±19.8 °C

[ Exact Mass ]:
170.968353

[ PSA ]:
26.02000

[ LogP ]:
2.05

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.626

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, peroxides, acids, acid chlorides, acid anhydrides, chloroformates. May be air sensitive.

[ Water Solubility ]:
<0.1 g/100 mL at 23 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BW9280000

CHEMICAL NAME :: Aniline, p-bromo-

CAS REGISTRY NUMBER :: 106-40-1

BEILSTEIN REFERENCE NO. :: 0742031

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C6-H6-Br-N

MOLECULAR WEIGHT :: 172.04

WISWESSER LINE NOTATION :: ZR DE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 456 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 289 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 248 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 50 umol/L

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2753 No. of Facilities: 174 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1744 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2753 No. of Facilities: 184 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 4703 (estimated) No. of Female Employees: 3745 (estimated)

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H311-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P312

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36/37-S36/37/39

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
BW9280000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29214210

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Synthetic and biological studies on thioxoquinazolinone substituted isoxazoles.

J. Environ Biol. 36 , 909-18, (2015)

Eighteen novel 5-phenyl-3-(substitutedthioxoquinazolinonyl) isoxazoles (5a-r) were synthesized by cycloaddition of various chalcones with hydroxylaminehydrochloride (NH2OH.HCl). All the newly synthesi...

Biopartitioning micellar chromatography to predict mutagenicity of aromatic amines.

Eur. J. Med. Chem. 42 , 1396-402, (2007)

Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry...

Acute metobromuron poisoning with severe associated methemoglobinemia. Identification of four metabolites in plasma and urine by LC-DAD, LC-ESI-MS, and LC-ESI-MS-MS.

J. Anal. Toxicol. 24(3) , 157-64, (2000)

A case of self poisoning with metobromuron, a urea derivative used as a herbicide, is reported. Severe methemoglobinemia observed at the admission (80%) disappeared only at day 11, and hemolysis appea...