o-Chloroacetophenone
Names
[ CAS No. ]:
2142-68-9
[ Name ]:
o-Chloroacetophenone
[Synonym ]:
1-(2-Chlorophenyl)ethanone
Acetophenone,2'-chloro
2’-Chloroacetophenone
o-Chloroacetophonone
Ethanone, 1- (2-chlorophenyl)-
2′-Chloroacetophenone
o-Chloroacetophenone
acetophenone, 2'-chloro-
o-chlorophenyl methyl ketone
EINECS 218-397-6
2'-Chloroacetophenone
2‘-Chloroacetophenone
MFCD00000560
Ethanone, 1-(2-chlorophenyl)-
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
195.5±13.0 °C at 760 mmHg
[ Melting Point ]:
52-56ºC
[ Molecular Formula ]:
C8H7ClO
[ Molecular Weight ]:
154.594
[ Flash Point ]:
89.6±11.0 °C
[ Exact Mass ]:
154.018539
[ PSA ]:
17.07000
[ LogP ]:
2.09
[ Vapour Pressure ]:
0.4±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.532
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AM6310000
- CHEMICAL NAME :
- Acetophenone, 2'-chloro-
- CAS REGISTRY NUMBER :
- 2142-68-9
- BEILSTEIN REFERENCE NO. :
- 1858916
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C8-H7-Cl-O
- MOLECULAR WEIGHT :
- 154.60
- WISWESSER LINE NOTATION :
- GR BV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1820 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CroHP# Personal Communication from H.P. Crocker, Ultimate Holding Co.-Reckitt & Colman Ltd., London, UK, Sept. 2, 1980 Volume(issue)/page/year: 02SEPT1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 880 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CroHP# Personal Communication from H.P. Crocker, Ultimate Holding Co.-Reckitt & Colman Ltd., London, UK, Sept. 2, 1980 Volume(issue)/page/year: 02SEPT1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7952 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22;R36/37/38
[ Safety Phrases ]:
S26-S36-S37/39-S45-S36/37/39-S28A
[ RIDADR ]:
UN 3416 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
AM6310000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1
[ HS Code ]:
2914509090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914700090
[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%
Articles
Sheng Wu Gong Cheng Xue Bao 19(2) , 206-11, (2003)
(R)-chlorprenaline, a selective activator of beta2 receptor and an effective drug for bronchitis and asthma, is industrially prepared from (R)-2'-chloro-1-phenyl-ethanol. In this communication, we des...
Spectral differentiation and gas chromatographic/mass spectrometric analysis of the lacrimators 2-chloroacetophenone and o-chlorobenzylidene malononitrile.J. Forensic Sci. 31(2) , 658-65, (1986)
2-Chloroacetophenone (CN) and o-chlorobenzylidene malononitrile (CS) are the most common chemical agents used as lacrimators in the United States. There is a lack of complete spectral data on these co...
Improving the enantioselective bioreduction of aromatic ketones mediated by Aspergillus terreus and Rhizopus oryzae: the role of glycerol as a co-solvent. Andrade LH, et al.Tetrahedron Asymmetry 20(13) , 1521-25, (2009)