Virginiamycin M1

Names

[ Name ]:
Virginiamycin M1

[Synonym ]:
Vernamycin A
Staphylomycin M1
STAPHYLOMYCIN
Antibiotic PA-114A1
pristinamycin component IIA
VIRGINIAMYCINE
MIKAMYCIN A
Pristinamycin IIA
VIRGINIAMYCIN M1
Streptogramin A

Biological Activity

[Description]:

Pristinamycin IIA (RP 12536) is a macrocyclic lactone peptolide antibiotic, derived from Streptomyces pristinaespiralis, which is a member of the streptogramin A group of antibiotics[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Bacterial[1]

[References]

[1]. Sezonov G, et al. Complete conversion of antibiotic precursor to pristinamycin IIA by overexpression of Streptomyces pristinaespiralis biosynthetic genes. Nat Biotechnol. 1997 Apr;15(4):349-53.

Chemical & Physical Properties

[ Density]:
1.26 g/cm3

[ Boiling Point ]:
825.2ºC at 760 mmHg

[ Melting Point ]:
165-170 °C

[ Molecular Formula ]:
C₂₈H₃₅N₃O₇

[ Molecular Weight ]:
525.59300

[ Flash Point ]:
452.9ºC

[ Exact Mass ]:
525.24800

[ PSA ]:
139.04000

[ LogP ]:
2.92610

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.586

[ Storage condition ]:
-20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

Articles

Purification and characterization of virginiamycin M1 reductase from Streptomyces virginiae.

Antimicrob. Agents Chemother. 42 , 2985-2988, (1998)

Virginiamycin M1 (VM1), produced by Streptomyces virginiae, is a polyunsaturated macrocyclic lactone antibiotic belonging to the virginiamycin A group. S. virginiae possesses an activity which stereos...

PapR6, a putative atypical response regulator, functions as a pathway-specific activator of pristinamycin II biosynthesis in Streptomyces pristinaespiralis.

J. Bacteriol. 197(3) , 441-50, (2015)

There are up to seven regulatory genes in the pristinamycin biosynthetic gene cluster of Streptomyces pristinaespiralis, which infers a complicated regulation mechanism for pristinamycin production. I...

VisG is eβential for biosynthesis of virginiamycin S, a streptogramin type B antibiotic, as a provider of the nonproteinogenic amino acid phenylglycine Fitria Ningsih, Shigeru Kitani, et al.

Microbiology 167 , 3213 - 3220, (2011)

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.