Virginiamycin S1

Names

[ Name ]:
Virginiamycin S1

[Synonym ]:
virginiamycin s1 (staphylomycin s, pa 114b2, antibiotic 899, antibiotic pa 114b2, antibiotic 1745z3b, factor s )
avilamycin

Biological Activity

[Description]:

Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Ningsih F, et al. VisG is essential for biosynthesis of virginiamycin S, a streptogramin type B antibiotic, as a provider of the nonproteinogenic amino acid phenylglycine. Microbiology. 2011 Nov;157(Pt 11):3213-20.

[2]. Ge B, et al. Purification and characterization of virginiamycin M1 reductase from Streptomyces virginiae. Sci Rep. 2017 Sep 8;7(1):11017.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₃H₄₉N₇O₁₀

[ Molecular Weight ]:
823.89000

[ Exact Mass ]:
823.35400

[ PSA ]:
224.72000

[ LogP ]:
2.06620

[ Vapour Pressure ]:
0mmHg at 25°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Purification and characterization of virginiamycin M1 reductase from Streptomyces virginiae.

Antimicrob. Agents Chemother. 42 , 2985-2988, (1998)

Virginiamycin M1 (VM1), produced by Streptomyces virginiae, is a polyunsaturated macrocyclic lactone antibiotic belonging to the virginiamycin A group. S. virginiae possesses an activity which stereos...

VisG is eβential for biosynthesis of virginiamycin S, a streptogramin type B antibiotic, as a provider of the nonproteinogenic amino acid phenylglycine Fitria Ningsih, Shigeru Kitani, et al.

Microbiology 167 , 3213 - 3220, (2011)