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diABZI STING agonist-1 (Tautomerism)

Names

[ CAS No. ]:
2138498-18-5

[ Name ]:
diABZI STING agonist-1 (Tautomerism)

Biological Activity

[Description]:

diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with an EC50s of 130 for human PBMCs.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> STING
Research Areas >> Inflammation/Immunology

[Target]

EC50: 130 nM (human STNG in PBMCs) [1].


[In Vitro]

diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with an EC50s of 130 for human PBMCs.

[In Vivo]

diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. At a concentration of 1 μM, diABZI STING agonist-1 (compound 3) demonstrates high selectivity against more than 350 kinases tested[1].

[References]

[1]. Ramanjulu JM, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Nov 7.


[Related Small Molecules]

CCCP | ADU-S100 ammonium salt | DMXAA (Vadimezan) | G10, STING signaling activator | C 176 | Cyclic-di-GMP | cGAMP | STING agonist-1(compound 3)trihydrochloride

Chemical & Physical Properties

[ Molecular Formula ]:
C42H51N13O7

[ Molecular Weight ]:
849.94

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds