2,2′-Dipyridyl disulfide

Names

[ Name ]:
2,2′-Dipyridyl disulfide

[Synonym ]:
di(2-pyridyl) disulfide
Bis(2-pyridinyl) disulfide
2,2'-Dipyridyl disuldide
pyridyl disulfide
2,2'-Dipyridyl disulfide
2-Pyridinyl disulfide
2,2'-DIHYDROXYDIPHENYLMETHANE
2,2'-Dithiobispyridine
1,2-Di(pyridin-2-yl)disulfane
2-Pyridin-2-yldisulfanylpyridine
MFCD00006287
EINECS 218-343-1
2,2‘-Dithiodipyridine
2-Dipyridyl disulfide
Aldrithiol 2
2,2′-dipyridyldisulfide
bis-pyridin-2-yl-disulfide
pyridyldisulfide
2,2'-Disulfanediyldipyridine
Aldrithiol
Bis(2-pyridyl) disulfide
2,2′-dipyridyl disulfide
Pyridine, 2,2'-dithiobis-
Aldrithiol™-2
2,2'-dipyridinyl disulfide
2,2'-Dithiodipyridine
4,4′-dipyridyldisulfide

Biological Activity

[Description]:

2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Formation of intramolecular S–S bonds can be dramatically accelerated by addition of a 2,2′-Dipyridyl disulfide (2-PDS) solution to an air-oxidized mixture of cysteine-containing peptides[1].

[References]

[1]. K Maruyama, et al. 2,2'-Bispyridyl disulfide rapidly induces intramolecular disulfide bonds in peptides. Peptides. 1999;20(7):881-4.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
356.1±17.0 °C at 760 mmHg

[ Melting Point ]:
56-58 °C(lit.)

[ Molecular Formula ]:
C₁₀H₈N₂S₂

[ Molecular Weight ]:
220.31

[ Flash Point ]:
169.2±20.9 °C

[ Exact Mass ]:
220.012894

[ PSA ]:
76.38000

[ LogP ]:
2.53

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.694

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
5 g/L (20 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/22;R37

[ Safety Phrases ]:
S36/37/39-S37/39-S25-S22

[ RIDADR ]:
UN3335 9

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

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