VU 6010572

Names

[ Name ]:
VU 6010572

Biological Activity

[Description]:

A potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 245 nM; show no inhibition for mGlu2 (IC50>30 uM); displays improved physiochemical properties and in vivo efficacy in a mouse tail suspension test (MED = 3 mg/kg i.p.).

[References]

References 1. Engers JL, et al. ACS Med Chem Lett. 2017 Aug 15;8(9):925-930. View Related Products by Target mGluR

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₈FNO₃

[ Molecular Weight ]:
339.366

Related Compounds

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