10,11-Dehydrocurvularin

Names

[ Name ]:
10,11-Dehydrocurvularin

[Synonym ]:
trans-dehydrocurvularin
E-dehydrocurvularin
10,11-dehydrocurvularin
8-dehydrocurvularin
Dehydrocurvularin
AmbotzLS-1091

Biological Activity

[Description]:

10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[References]

[1]. Xu Y, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-47.

[2]. Cochrane RV, et al. Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem. 2015 Nov;16(17):2479-83.

Chemical & Physical Properties

[ Density]:
1.225 g/cm3

[ Boiling Point ]:
576.3ºC at 760 mm

[ Molecular Formula ]:
C₁₆H₁₈O₅

[ Molecular Weight ]:
290.31100

[ Flash Point ]:
216.7ºC

[ Exact Mass ]:
290.11500

[ PSA ]:
83.83000

[ LogP ]:
2.49480

[ Vapour Pressure ]:
7.02E-14mmHg at 25°C

[ Index of Refraction ]:
1.555

Safety Information

[ HS Code ]:
2932999099

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%