γ-Amanitin

Names

[ Name ]:
γ-Amanitin

[Synonym ]:
2-[34-sec-Butyl-8,22-dihydroxy-13-(3-hydroxy-2-butanyl)-27-oxido-2,5,11,14,30,33,36,39-octaoxo-27-thia-3,6,12,15,25,29,32,35,38-nonaazapentacyclo[14.12.11.0.0.0]nonatriaconta-18(26 ),19,21,23-tetraen-4-yl]acetamide
9,18-(Iminoethanoiminoethanoiminoethanoiminomethano)pyrrolo[1',2':8,9][1,5,8,11,14]thiatetraazacyclooctadecino[18,17-b]indole-6-acetamide, 1,2,3,5,6,7,8,9,10,12,17,18,19,20,21,22,23,23a-octadecahydro-2,14-dihydroxy-21-(2-hydroxy-1-methylpropyl)-29-(1-methylpropyl)-5,8,20,23,24,27,30,33-octaoxo-, 11-oxide

Biological Activity

[Description]:

γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin (HY-19610) and β-Amanitin (HY-125586)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[Target]

Traditional Cytotoxic Agents

[References]

[1]. Gamma-Amanitin

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
1566.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₉H₅₄N₁₀O₁₃S

[ Molecular Weight ]:
902.970

[ Flash Point ]:
901.2±34.3 °C

[ Exact Mass ]:
902.359253

[ PSA ]:
405.28000

[ LogP ]:
-7.98

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.684

Safety Information

[ RIDADR ]:
UN 1544 6.1/PG 1

Related Compounds

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