21150-23-2
21150-23-2 structure
- Name: γ-Amanitin
- Chemical Name: 2-[34-sec-Butyl-8,22-dihydroxy-13-(3-hydroxy-2-butanyl)-27-oxido-2,5,11,14,30,33,36,39-octaoxo-27-thia-3,6,12,15,25,29,32,35,38-nonaazapentacyclo[14.12.11.06,10.018,26.019,24]nonatriaconta-18(26),19,21,23-tetraen-4-yl]acetamide
- CAS Number: 21150-23-2
- Molecular Formula: C39H54N10O13S
- Molecular Weight: 902.970
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
- Create Date: 2018-06-17 19:46:39
- Modify Date: 2024-01-04 10:38:54
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γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin (HY-19610) and β-Amanitin (HY-125586)[1].
| Name | 2-[34-sec-Butyl-8,22-dihydroxy-13-(3-hydroxy-2-butanyl)-27-oxido-2,5,11,14,30,33,36,39-octaoxo-27-thia-3,6,12,15,25,29,32,35,38-nonaazapentacyclo[14.12.11.06,10.018,26.019,24]nonatriaconta-18(26),19,21,23-tetraen-4-yl]acetamide |
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| Synonyms |
2-[34-sec-Butyl-8,22-dihydroxy-13-(3-hydroxy-2-butanyl)-27-oxido-2,5,11,14,30,33,36,39-octaoxo-27-thia-3,6,12,15,25,29,32,35,38-nonaazapentacyclo[14.12.11.0.0.0]nonatriaconta-18(26 ),19,21,23-tetraen-4-yl]acetamide
9,18-(Iminoethanoiminoethanoiminoethanoiminomethano)pyrrolo[1',2':8,9][1,5,8,11,14]thiatetraazacyclooctadecino[18,17-b]indole-6-acetamide, 1,2,3,5,6,7,8,9,10,12,17,18,19,20,21,22,23,23a-octadecahydro-2,14-dihydroxy-21-(2-hydroxy-1-methylpropyl)-29-(1-methylpropyl)-5,8,20,23,24,27,30,33-octaoxo-, 11-oxide |
| Description | γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin (HY-19610) and β-Amanitin (HY-125586)[1]. |
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| Related Catalog | |
| Target |
Traditional Cytotoxic Agents |
| References |
[1]. Gamma-Amanitin |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 1566.5±65.0 °C at 760 mmHg |
| Molecular Formula | C39H54N10O13S |
| Molecular Weight | 902.970 |
| Flash Point | 901.2±34.3 °C |
| Exact Mass | 902.359253 |
| PSA | 405.28000 |
| LogP | -7.98 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.684 |
| RIDADR | UN 1544 6.1/PG 1 |
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