3-(3,4-Dimethoxyphenyl)propionic acid

Names

[ Name ]:
3-(3,4-Dimethoxyphenyl)propionic acid

[Synonym ]:
3,4-Dimethoxy-benzenepropanoic acid
3-(3,4-Dimethoxyphenyl)propionic Acid
3-(3,4-Dimethoxyphenyl)propanoic acid
Benzenepropanoic acid, 3,4-dimethoxy-
3,4-Dimethoxyhydrocinnamic Acid
MFCD00002774
Benzenepropanoic acid,3,4-dimethoxy
3,5-Dimethoxyphenylpropionic acid
3-3,4-Dimethoxyphenylpropionic Acid
3-(3',4'-dimethoxyphenyl)propanoic acid
3-(4',5'-dimethoxyphenyl)propionic acid
EINECS 218-288-3
Donepezil Impurity 34

Biological Activity

[Description]:

3-(3,4-Dimethoxyphenyl)propanoic acid is an orally active short-chain fatty acids (SCFAs). 3-(3,4-Dimethoxyphenyl)propanoic acid stimulates γ globin gene expression, erythropoiesis in vivo and is used for the β hemoglobinopathies and other anemias[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[In Vivo]

3-(3,4-Dimethoxyphenyl)propanoic acid (50, 150 mg/kg of iv or 50, 150, 200 mg/kg of orally) achieves concentrations significantly higher than targeted plasma levels for several hours after single 50 to 150 mg/kg doses[1].

[References]

[1]. Pace BS, et al. Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo. lood. 2002 Dec 15;100(13):4640-8.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
344.2±27.0 °C at 760 mmHg

[ Melting Point ]:
96-97 °C(lit.)

[ Molecular Formula ]:
C₁₁H₁₄O₄

[ Molecular Weight ]:
210.227

[ Flash Point ]:
132.0±17.2 °C

[ Exact Mass ]:
210.089203

[ PSA ]:
55.76000

[ LogP ]:
1.58

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.522

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo.

Blood 100(13) , 4640-8, (2002)

Orally bioactive compounds that induce gamma globin gene expression at tolerable doses are needed for optimal treatment of the beta-hemoglobinopathies. Short-chain fatty acids (SCFAs) of 2 to 6 carbon...

Metal-cinnamic acids interactions. Part IV. Synthesis, study and antimicrobial activity of copper (II) complexes of 3, 4-dimethoxyhydrocinnamic acid. Zoroddu MA and Berardi E.

Transition Met. Chem. (London) 14(4) , 269-72, (1989)