5-HT2C agonist-3

Names

[ Name ]:
5-HT2C agonist-3

Biological Activity

[Description]:

5-HT2C agonist-3 ((+)-19) is a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM). 5-HT2C agonist-3 has antipsychotic drug-like activity. 5-HT2C agonist-3 blocks Amphetamine-induced hyperactivity[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

EC50: 24 nM, Ki: 78 nM (5-HT2C)[1]

[References]

[1]. Guiping Zhang, et al. Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications. J. Med. Chem. 2017, 60, 14, 6273–6288.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₃ClFNO₂

[ Molecular Weight ]:
351.84

Related Compounds

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