2,4-Difluorophenylethynylcobalamin

Names

[ CAS No. ]:
2101750-19-8

[ Name ]:
2,4-Difluorophenylethynylcobalamin

Biological Activity

[Description]:

2,4-Difluorophenylethynylcobalamin is a potential B12 antivitamin via binding to human B12 -processing enzyme CblC with high affinity (KD=130 nm). 2,4-Difluorophenylethynylcobalamin withstood tailoring by CblC, and stabilizes the ternary complex with the cosubstrate glutathione (GSH)[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[Target]

B12 -processing enzyme CblC[1]


[References]

[1]. Ruetz M, et al. Antivitamin B12 Inhibition of the Human B12 -Processing Enzyme CblC: Crystal Structure of an Inactive Ternary Complex with Glutathione as the Cosubstrate. Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7387-7392.  

Chemical & Physical Properties

[ Molecular Formula ]:
C70H91CoF2N13O14P

[ Molecular Weight ]:
1466.45

Related Compounds

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