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isotanshinone I

Names

[ CAS No. ]:
20958-17-2

[ Name ]:
isotanshinone I

[Synonym ]:
Isotanshinon-I
4,8-Dimethylphenanthro[3,2-b]furan-7,11-dione

Biological Activity

[Description]:

Isotanshinone I has inhibitory activity against α-glucosidase and formation of AGE, with IC50s of 1.13, 0.432 μM for α-glucosidase and AGE, respectively.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Infection
Natural Products >> Flavonoids

[Target]

IC50: 1.13μM (α-glucosidase), 0.432 μM (AGE)[1].


[References]

[1]. Ma HY, et al. Constituents with α-glucosidase and advanced glycation end-product formation inhibitory activities from Salvia miltiorrhiza Bge. J Nat Med. 2011 Jan;65(1):37-42.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.324±0.06 g/cm3

[ Boiling Point ]:
495.8±34.0 °C at 760 mmHg

[ Melting Point ]:
219 ºC

[ Molecular Formula ]:
C18H12O3

[ Molecular Weight ]:
276.28600

[ Exact Mass ]:
276.07900

[ PSA ]:
47.28000

[ LogP ]:
3.82500

[ Water Solubility ]:
Insuluble (2.1E-5 g/L) (25 ºC)

Related Compounds