KY-02061

Names

[ CAS No. ]:
2093406-88-1

[ Name ]:
KY-02061

Biological Activity

[Description]:

KY-02061 is a small-molecule inhibitor of Dishevelled-CXXC5 interaction with IC50 of 24 uM in vitro binding assay; increases the activation of the Wnt/β-catenin pathway in a dose-dependent manner as revealed by the TOPflash reporter assay, ALP activity also increased in a dose‐dependent manner in KY-02061-treated primary osteoblast cells, increases levels of Runx2, an osteoblast differentiation marker, and β-catenin

[References]

References 1. Kim HY, et al. EMBO Mol Med. 2016 Apr 1;8(4):375-87. View Related Products by Target Dishevelled

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₃NO₇S

[ Molecular Weight ]:
445.486

Related Compounds

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