KY-02327
Names
[ CAS No. ]:
2093407-25-9
[ Name ]:
KY-02327
Biological Activity
[Description]:
KY-02327 is an orally active, small molecule inhibitor of the Dishevelled (Dvl)-CXXC5 interaction with IC50 of 3.1 uM, a metabolically stabilized KY-02061 analog; KY-02327 is more stable by 2.3-fold and 1.3-fold than KY-02061 in rat liver microsomes and in human hepatocytes, respectively; shows enhanced effect on induction of ALP activity of osteoblast cells compared with KY-02061; activates the Wnt/β-catenin pathway, promotes osteoblast differentiation, and rescues BMD, bone volume, and trabecular bone structures in variectomized (OVX) mouse model.
[References]
References 1. Kim HY, et al. EMBO Mol Med. 2016 Apr 1;8(4):375-87. View Related Products by Target Dishevelled
Chemical & Physical Properties
[ Molecular Formula ]:
C20H27N3O4
[ Molecular Weight ]:
373.453
[ Storage condition ]:
-20°C