2093406-88-1
2093406-88-1 structure
- Name: KY-02061
- Chemical Name: KY-02061
- CAS Number: 2093406-88-1
- Molecular Formula: C22H23NO7S
- Molecular Weight: 445.486
- Create Date: 2020-01-12 00:45:40
- Modify Date: 2024-02-11 16:42:49
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KY-02061 is a small-molecule inhibitor of Dishevelled-CXXC5 interaction with IC50 of 24 uM in vitro binding assay; increases the activation of the Wnt/β-catenin pathway in a dose-dependent manner as revealed by the TOPflash reporter assay, ALP activity also increased in a dose‐dependent manner in KY-02061-treated primary osteoblast cells, increases levels of Runx2, an osteoblast differentiation marker, and β-catenin
| Name | KY-02061 |
|---|
| Description | KY-02061 is a small-molecule inhibitor of Dishevelled-CXXC5 interaction with IC50 of 24 uM in vitro binding assay; increases the activation of the Wnt/β-catenin pathway in a dose-dependent manner as revealed by the TOPflash reporter assay, ALP activity also increased in a dose‐dependent manner in KY-02061-treated primary osteoblast cells, increases levels of Runx2, an osteoblast differentiation marker, and β-catenin |
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| References | References 1. Kim HY, et al. EMBO Mol Med. 2016 Apr 1;8(4):375-87. View Related Products by Target Dishevelled |
| Molecular Formula | C22H23NO7S |
|---|---|
| Molecular Weight | 445.486 |