AOH1160

Names

[ CAS No. ]:
2089314-57-6

[ Name ]:
AOH1160

Biological Activity

[Description]:

AOH1160 is a potent, first-in-class, orally available small molecule proliferating cell nuclear antigen (PCNA) inhibitor, interferes with DNA replication, blocks homologous recombination-mediated DNA repair, causes cell-cycle arrest and induces apoptosis. AOH1160 selectively kills many types of cancer cells (mean GI50=330 nM) without causing significant toxicity to a broad range of nonmalignant cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[Target]

IC50: PCNA[1]

[References]

[1]. Gu L, et al. The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA. Clin Cancer Res. 2018 Dec 1;24(23):6053-6065.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₀N₂O₃

[ Molecular Weight ]:
396.44

Related Compounds

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