2089314-57-6

2089314-57-6 structure

Name: AOH1160
Chemical Name: AOH1160
CAS Number: 2089314-57-6
Molecular Formula: C₂₅H₂₀N₂O₃
Molecular Weight: 396.44
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2019-10-09 18:23:29
Modify Date: 2024-01-09 20:55:37
AOH1160 is a potent, first-in-class, orally available small molecule proliferating cell nuclear antigen (PCNA) inhibitor, interferes with DNA replication, blocks homologous recombination-mediated DNA repair, causes cell-cycle arrest and induces apoptosis. AOH1160 selectively kills many types of cancer cells (mean GI50=330 nM) without causing significant toxicity to a broad range of nonmalignant cells[1].

Name	AOH1160

Description	AOH1160 is a potent, first-in-class, orally available small molecule proliferating cell nuclear antigen (PCNA) inhibitor, interferes with DNA replication, blocks homologous recombination-mediated DNA repair, causes cell-cycle arrest and induces apoptosis. AOH1160 selectively kills many types of cancer cells (mean GI50=330 nM) without causing significant toxicity to a broad range of nonmalignant cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Target	IC50: PCNA[1]
References	[1]. Gu L, et al. The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA. Clin Cancer Res. 2018 Dec 1;24(23):6053-6065.

Molecular Formula	C₂₅H₂₀N₂O₃
Molecular Weight	396.44