VBIT-3

Names

[ CAS No. ]:
2088463-66-3

[ Name ]:
VBIT-3

Biological Activity

[Description]:

VBIT-3 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 31.3 μM. VBIT-3, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cardiovascular Disease

Research Areas >> Neurological Disease

[Target]

Kd: 31.3 μM (VDAC1)[1] Apoptosis[1]

[In Vitro]

VBIT-3 targets the mitochondrial protein VDAC1, inhibit apoptosis and protect against mitochondria dysfunction[1]. VBIT-3 (0.1-10 μM) inhibits VDAC1 oligomerization, Cyto c release from mitochondria and apoptosis in HEK-293 cells with IC50s of 8.8±0.56 μM, 6.6±1.03 μM, and 7.5±0.27 μM, respectively[1]. Apoptosis Analysis[1] Cell Line: HEK-293 cells Concentration: 0.1, 1, and 10 μM Incubation Time: Result: Inhibited apoptosis with an IC50 of 7.5±0.27μM.

[References]

[1]. Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₉ClF₃N₃O₃

[ Molecular Weight ]:
453.84

Related Compounds

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